Commentaries and discussion on seminal papers in molecular simulation.


Ultra-sensitive binding response: Superselectivity and the role of combinatorial entropy in binding

Commentary by

Stefano Angioletti-Uberti; Tine Curk
Department of Materials, Imperial College London, UK; Department of Materials Science and Engineering, Johns Hopkins University, USA

on

F.Martinez-Veracoechea and D.Frenkel, “Designing super selectivity in multivalent nano-particle binding”, PNAS, 108:10963 (2011)


Statement of Significance

Multivalency refers to the possibility of both synthetic and natural constructs, e.g., nanoparticles or viruses, to bind their target via multiple ligand-receptor bonds. Super-selectivity is a peculiar property of multivalent binding, first rationalised by Martinez-Veracoechea and Frenkel, and refers to the almost step-like response of the binding probability with respect to the number of receptors on the target. This commentary discusses the physical origins of this phenomenon, and how (combinatorial) entropy provides a fruitful point of view to understand ultra-sensitive responses involving multivalent agents.


Commentary

Read the Commentary (PDF)


Discussion Thread



How to cite

Cite the commentary as:

Stefano Angioletti-Uberti; Tine Curk, “Ultra-sensitive binding response: Superselectivity and the role of combinatorial entropy in binding”, KIM REVIEW, Volume 2, Article 02, 2024. DOI: 10.25950/4f38ca7d



KIM REVIEW is a KIM Initiative project